�ImClone Systems Incorporated (NASDAQ: IMCL), a global leader in the development and commercialization of novel antibodies to treat cancer, today announced that its disease-directed Phase 2 clinical trial in patients with advance prostate crab randomized to treatment with either IMC-A12 or IMC-1121B plus mitoxantrone and deltasone has commenced patient enrollment. IMC-A12 and IMC-1121B are two sanative candidates in ImClone's proprietary receptor-targeted antibody pipeline. IMC-A12 is ImClone's fully human, IgG1 anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody and IMC-1121B is its fully human, IgG1 anti-vascular growth divisor receptor-2 (VEGFR-2) monoclonal antibody.
This multicenter, randomized open-label Phase 2 single-arm study is enrolling patients with metastatic androgen-independent prostate cancer the Crab who take developed disease progression during or inside 60 years of receiving docetaxel-based chemotherapy or demonstrated intolerance to docetaxel-based therapy. A total of 132 patients are expected to be enrolled at various centers, including those that participate in the Department of Defense's Prostate Cancer Consortium. This Phase 2 study is designed to evaluate the efficacy and safety of both IMC-A12 and IMC-1121B combined with mitoxantrone and prednisone. IMC-A12 and IMC-1121B are administered weekly, whereas mitoxantrone is administered every three weeks with oral daily liquid Pred.
"We are very proud of about
Monday, 8 September 2008
Friday, 29 August 2008
Cook Medical Drives Discussion On Peyronie's Disease With New Resources On MensHealthPD.com
�In its ongoing dedication to persist at the forefront of physician and patient department of Education, Cook Medical announced that new resources are available on MensHealthPD.com including Q&A videos featuring three new expert physicians, updated medical research and multiple links to accredited industry sites. MensHealthPD.com is an educational microsite consecrated to providing physicians, men and their partners with information about the symptoms, treatment options and in vogue research on Peyronie's disease, a common form of erectile dysfunction affecting more than than 1.4 1000000 men in the United States1 .
Featuring world-renowned Peyronie's disease specialists, MensHealthPD.com has added trey additional experts to its group of physician contributors who appear in streaming video answering frequently asked questions circumferent Peyronie's disease. Each mD expert answers questions related to to the signs, symptoms and discourse of Peyronie's disease. Site visitors consume the alternative of viewing each physician's individual response in a short streaming video or reading the response in transcript form.
MensHealthPD.com besides now features a bibliography of golf links to "suggested reading" on Peyronie's. Compiled by the site's team of dr. experts, the links postulate patients and clinicians to what ar considered to be pivotal, peer-reviewed articles on research and information exploring the causes and treatments of Peyronie's disease. The heel is an enhancement to the existing comprehensive list of golf links to articles on virtually all nonsurgical and surgical options for Peyronie's intervention. Visitors to menshealthpd.com also have new options of linking to a variety of web sites related to Peyronie's disease, erectile dysfunction and sexual health.
"There are many unanswered questions about Peyronie's Disease and our goal is to ensure patients and physicians have a one-stop resource providing the information they need. Therefore, we are dedicated to continually providing fresh content and resources to the visitors of MensHealthPD.com," said Jerry French, Senior Vice President and Global Strategic Business Unit Leader for Cook Urology. "The ongoing aggregation of the most recent inquiry and published scientific data around Peyronie's disease enables MensHealthPD.com to serve as a decisive resource for patients and physicians seeking thorough, true and cutting-edge information."
Launched in February 2008, MensHealthPD.com, is owned and maintained by Cook Medical and is intentional to provide the up-to-the-minute information on Peyronie's disease. The interactional site offers medical professionals, patients and their partners public and physician forums for discussing Peyronie's disease, posting questions and sharing personal experiences about the condition.
About Peyronie's Disease
The disease is linked to erectile disfunction in 20 to 40 percent of the sufferers and is characterized by the formation of a plaque or hardened cicatrice tissue below the skin of a man's penis. The scarring is non-cancerous and may lead to a painful erection and curvature of the member during erection.
About MensHealthPD.com
MensHealthPD.com is owned and maintained by Cook Medical. Cook is committed to fostering an ongoing word around clinically proven information to promote the continued improvement of patient care and promotion of treatments.
About Cook Medical
Cook Medical was one of the first companies to help popularize interventional medicine, pioneering many of the devices now commonly used global to execute minimally invasive medical procedures. Today, the company integrates minimally invasive medical device design, biopharma, gene and cell therapy, and biotech to enhance patient refuge and improve clinical outcomes in the fields of aortic intervention; interventional cardiology; critical charge medicine; gastroenterology; radiology, peripheral vascular, ivory access and oncology; surgical operation and soft tissue rectify; urology; and assisted reproductive technology, gynaecology and bad obstetrics. Founded in 1963 and operated as a family-held secret corporation, Cook is a past success of the prestigious Medical Device Manufacturer of the Year Award from Medical Device & Diagnostic Industry magazine. For more information, visit hTTP://www.cookmedical.com
1 http://www.wrongdiagnosis.
Featuring world-renowned Peyronie's disease specialists, MensHealthPD.com has added trey additional experts to its group of physician contributors who appear in streaming video answering frequently asked questions circumferent Peyronie's disease. Each mD expert answers questions related to to the signs, symptoms and discourse of Peyronie's disease. Site visitors consume the alternative of viewing each physician's individual response in a short streaming video or reading the response in transcript form.
MensHealthPD.com besides now features a bibliography of golf links to "suggested reading" on Peyronie's. Compiled by the site's team of dr. experts, the links postulate patients and clinicians to what ar considered to be pivotal, peer-reviewed articles on research and information exploring the causes and treatments of Peyronie's disease. The heel is an enhancement to the existing comprehensive list of golf links to articles on virtually all nonsurgical and surgical options for Peyronie's intervention. Visitors to menshealthpd.com also have new options of linking to a variety of web sites related to Peyronie's disease, erectile dysfunction and sexual health.
"There are many unanswered questions about Peyronie's Disease and our goal is to ensure patients and physicians have a one-stop resource providing the information they need. Therefore, we are dedicated to continually providing fresh content and resources to the visitors of MensHealthPD.com," said Jerry French, Senior Vice President and Global Strategic Business Unit Leader for Cook Urology. "The ongoing aggregation of the most recent inquiry and published scientific data around Peyronie's disease enables MensHealthPD.com to serve as a decisive resource for patients and physicians seeking thorough, true and cutting-edge information."
Launched in February 2008, MensHealthPD.com, is owned and maintained by Cook Medical and is intentional to provide the up-to-the-minute information on Peyronie's disease. The interactional site offers medical professionals, patients and their partners public and physician forums for discussing Peyronie's disease, posting questions and sharing personal experiences about the condition.
About Peyronie's Disease
The disease is linked to erectile disfunction in 20 to 40 percent of the sufferers and is characterized by the formation of a plaque or hardened cicatrice tissue below the skin of a man's penis. The scarring is non-cancerous and may lead to a painful erection and curvature of the member during erection.
About MensHealthPD.com
MensHealthPD.com is owned and maintained by Cook Medical. Cook is committed to fostering an ongoing word around clinically proven information to promote the continued improvement of patient care and promotion of treatments.
About Cook Medical
Cook Medical was one of the first companies to help popularize interventional medicine, pioneering many of the devices now commonly used global to execute minimally invasive medical procedures. Today, the company integrates minimally invasive medical device design, biopharma, gene and cell therapy, and biotech to enhance patient refuge and improve clinical outcomes in the fields of aortic intervention; interventional cardiology; critical charge medicine; gastroenterology; radiology, peripheral vascular, ivory access and oncology; surgical operation and soft tissue rectify; urology; and assisted reproductive technology, gynaecology and bad obstetrics. Founded in 1963 and operated as a family-held secret corporation, Cook is a past success of the prestigious Medical Device Manufacturer of the Year Award from Medical Device & Diagnostic Industry magazine. For more information, visit hTTP://www.cookmedical.com
1 http://www.wrongdiagnosis.
Tuesday, 19 August 2008
Verve, Kings Of Leon, Amy Winehouse for V Festival Staffordshire day one
The Verve are set to headline the V Stage tonight (August 16) at the Staffordshire leg of the V Festival � the first night of the bash.
The band are set to flirt after performances from Kings Of Leon, Amy Winehouse, Lenny Kravitz, The Feeling and Girls Aloud.
Before the aforementioned acts of the Apostles play The Stranglers are set to kick off proceedings on the stage, followed by Squeeze.
The Verve will be going head-to-head with Kaiser Chiefs, world Health Organization are scheduled to headline the 4music stage at the like time as their set.
The Leeds band will be playing afterwards The Zutons, The View and Reverend And The Makers.
Elsewhere on the land site The Chemical Brothers headline the JJB Arena after The Charlatans and Hot Chip.
Guillemots are set to headline the Virgin Mobile Union collapsible shelter after Echo And The Bunnymen and Young Knives, with Goldie Lookin Chain and Noah and the Whale as well set to play in the tent.
Keep checking NME.COM for the latest news show, pictures, videos and blogs live from V Festival all weekend.
More info
The band are set to flirt after performances from Kings Of Leon, Amy Winehouse, Lenny Kravitz, The Feeling and Girls Aloud.
Before the aforementioned acts of the Apostles play The Stranglers are set to kick off proceedings on the stage, followed by Squeeze.
The Verve will be going head-to-head with Kaiser Chiefs, world Health Organization are scheduled to headline the 4music stage at the like time as their set.
The Leeds band will be playing afterwards The Zutons, The View and Reverend And The Makers.
Elsewhere on the land site The Chemical Brothers headline the JJB Arena after The Charlatans and Hot Chip.
Guillemots are set to headline the Virgin Mobile Union collapsible shelter after Echo And The Bunnymen and Young Knives, with Goldie Lookin Chain and Noah and the Whale as well set to play in the tent.
Keep checking NME.COM for the latest news show, pictures, videos and blogs live from V Festival all weekend.
More info
Saturday, 9 August 2008
Tuesday, 1 July 2008
Nicole Richie to guest star on NBC's 'Chuck'; episode to air in fall
NEW YORK - As Paris Hilton's sidekick on "The Simple Life," Nicole Richie showed a flair for comedy - and an impish glee at cracking jokes at others' expense.
The 26-year-old celebutante will again display a caustic streak in an upcoming guest spot on NBC's "Chuck," portraying the mean-spirited high school nemesis of undercover CIA agent Sarah Walker (Yvonne Strahovski).
In the episode, which will air this fall, Sarah must confront Richie's character when she is forced to attend her 10-year high school reunion for a mission with fellow agent Chuck Bartowski (Zachary Levi) as her date.
"Nicole auditioned for the part and was very funny," executive producer Josh Schwartz said in a statement Wednesday. "This role is a great opportunity for her to show off her comedic skills and be diabolically evil and kick some butt. It's going to be really fun."
She has previously guest starred on TV's "American Dreams" and "8 Simple Rules ... for Dating My Teenage Daughter."
Richie and her beau, Good Charlotte rocker Joel Madden, welcomed daughter Harlow Winter Kate Madden in January.
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NBC is owned by General Electric Co.
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On the Net:
http://www.nbc.com/
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Monday, 16 June 2008
Sheen Urges The Elderly To Get Active
Martin Sheen is urging his fellow pensioners to find ways to help others in an effort to end the trend of the elderly drinking themselves to death. The actor, 68, is staggered by statistics about the rise in alcoholism among retired people and, as an active member of Alcoholics Anonymous, he's determined to make a change. Sheen tells the new issues of America's Aarp magazine for the elderly he believes many retirees turn to booze when loved ones die and they find themselves feeling lonely. He says, "Suddenly they're alone; they spiral much quicker. "What revives so many elderly and people who have lost spouses is getting back in there. Go back and serve, teach, find people who need your help. "When you become disconnected, you get farther and farther from the shore, and you don't realise how far you've drifted, and then suddenly you're in the deep water and you're alone."
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Sunday, 8 June 2008
Red tape sees Kiwi rockers rolled out of UK
New Zealand band Opshop have been kicked out of Britain, but for red tape not rock 'n' roll reasons.
Visa trouble forced them to cancel their Edinburgh show on Saturday, the first of a three-show, 10-day promotional tour, The New Zealand Herald reported.
Siren record label representative Tracy Magan said management thought Opshop could travel under the visa-waiver programme because they wouldn't be making any money during the tour.
But after rule changes the programme had "tightened up" significantly.
In the past three months there had been a 12 per cent increase in expulsions, and bands from around the world had been caught short.
Ms Magan said visas were being sorted out and the band - Jason Kerrison, Matt Treacy, Bobby Kennedy and Clint Harris - would be back in the UK by the end of the week.
Their song Maybe is the most successful of all time on New Zealand radio.
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Simple Minds - Simple Minds To Hit Studio For First Time In 27 Years
Reunited rockers SIMPLE MINDS are set to record together for the first time in 27 years - as part of their 30th anniversary celebrations.
Founding members Brian MCGee, Derek Forbes and Mick MCNeil will join existing members Jim Kerr and Charlie Burchill to play at Nelson Mandela's 90th birthday concert in London in June (08), and they hope their stage comeback will inspire them enough to record some new material.
And the band are looking to have the new songs ready for the start of their reunion tour of the U.K. later this year (08) - as a special treat for their dedicated fans.
The group's original line-up parted ways in 1991, leaving just Kerr and Burchill to continue recording under the name.
And frontman Kerr is excited about hitting the studio with the original line-up.
He says, "Of course I am excited with the prospect of working with the original line - up once more. I had always believed that the day would come when we would get the opportunity to do so.
"We have a lot to live up to, but we intend to have some fun attempting to do just that."
The Simple Minds tour kicks off in Manchester, England on 27 November (08).
See Also
- Music Impresario and Long-Time Humanitarian Quincy Jones Comments Publicly About China and the Darfur Crisis and His Role as an Artistic Advisor to the Opening Ceremonies of the 2008 Beijing Olympic Games
- Indie prison flicks are breakout trend
- Anne Murray
- Desperate Housewives - Housewives Audience Slow To Return
Nick Parkin
Artist: Nick Parkin
Genre(s):
Ambient
Discography:
Island Of Dust
Year: 1999
Tracks: 9
Descent
Year: 1996
Tracks: 9
Grant Threatens Paparazzo
Actor Hugh Grant came close to losing his temper with the paparazzi on Saturday when he reportedly threatened to throw one photographer through a window. The star, 47, was caught leaving London nightclub Nam Long-Le Shaker with a mystery woman in the early hours when he spotted the snappers taking his photo. Enraged by their presence, he allegedly raged to one paparazzo: "How about I push you through that window?" But Grant apparently lost his nerve and turned to run off - abandoning the leggy brunette outside the club.
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See Also
National Student Music Awards details revealed
Details of this year's National Student Music Awards have been announced, with three regional heats set to take place in March.
The awards, which have been previously won by Delorentos, offer Third Level student musicians the opportunity to perform before members of the Irish Music Industry including journalists, broadcasters, A&R personnel, agents and bookers.
A panel of industry experts will pick 12 of the best bands to perform at three heats around the country.
Four selected entrants will compete at each of the three regional heats which take place in UCD, Dublin (6 March); NUIG, Galway (13 March) and Cyprus Avenue, Cork (19 March).
The overall final will take place in The Village, Dublin on 24 April.
The prize up for grabs includes recording time, a cash prize, CD duplication, rehearsal time, a media interview, consultation with a music lawyer and a photography session.
Closing date for entries is 12 February and entry is open to any act that has at least one member in full-time Third Level education in Ireland.
Demos should be sent to National Student Music Awards, Suite 49, 184 Lower Rathmines Road, Dublin 6.
The awards, which have been previously won by Delorentos, offer Third Level student musicians the opportunity to perform before members of the Irish Music Industry including journalists, broadcasters, A&R personnel, agents and bookers.
A panel of industry experts will pick 12 of the best bands to perform at three heats around the country.
Four selected entrants will compete at each of the three regional heats which take place in UCD, Dublin (6 March); NUIG, Galway (13 March) and Cyprus Avenue, Cork (19 March).
The overall final will take place in The Village, Dublin on 24 April.
The prize up for grabs includes recording time, a cash prize, CD duplication, rehearsal time, a media interview, consultation with a music lawyer and a photography session.
Closing date for entries is 12 February and entry is open to any act that has at least one member in full-time Third Level education in Ireland.
Demos should be sent to National Student Music Awards, Suite 49, 184 Lower Rathmines Road, Dublin 6.
Atonement star in new Dublin film?
'Atonement' star James McAvoy and his wife, 'Shameless' star Anne-Marie Duff, are in negotiations about playing the lead roles in a new movie which will be shot in Dublin.
The Hollywood Reporter says that the comedy thriller 'Perrier's Bounty' has been written by playwright Mark O'Rowe and will be directed by 'Paths to Freedom' director Ian Fitzgibbon.
The film tells the story of three people on the run in Dublin from a gangster named Perrier, who is out to save face following the accidental killing of one of his gang.
'Perrier's Bounty' is due to shoot in Dublin later this year.
McAvoy and Duff were among the stars at the BAFTAs in London on Sunday night. Visit our BAFTAs gallery here.
The Hollywood Reporter says that the comedy thriller 'Perrier's Bounty' has been written by playwright Mark O'Rowe and will be directed by 'Paths to Freedom' director Ian Fitzgibbon.
The film tells the story of three people on the run in Dublin from a gangster named Perrier, who is out to save face following the accidental killing of one of his gang.
'Perrier's Bounty' is due to shoot in Dublin later this year.
McAvoy and Duff were among the stars at the BAFTAs in London on Sunday night. Visit our BAFTAs gallery here.
Ephel Duath
Artist: Ephel Duath
Genre(s):
Metal: Death,Black
Rock
Discography:
The Painter's Palette
Year: 2003
Tracks: 9
Rephormula
Year: 2002
Tracks: 13
Phormula
Year: 2000
Tracks: 8
One of Italy's to the highest degree ambitious toilsome metal bands, Padova's Ephel Duath coalesce the realms of end, black, and progressive metal (think Cynic meets Solefald), and were founded in 1998, ab initio as a studio apartment figure, by the multi-talented pair of Davide Tiso (vocals, guitars, keyboards) and Giuliano Mogicato (vocals, guitars, basso). After marketing over 1,000 copies of their "Opera" demonstration (and topping MP3.com's wakeless metallic element charts with over 20,000 free downloads!), the geminate released 2000's anything merely formulaic Phormula to match amounts of raving and panning (but never less than amazed) reviews -- later augmenting and reissuing it as Rephormula later sign language with Earache Records subsidiary Elitist. Ephel Duath's side by side feat was 2003's wildly eclectic The Painters Palette, which arguably took even greater creative risks by incorporating electronics and loose malarkey, among other sonic accents. But, like its 2005 follow-up, Pain Necessary to Know, it found Tiso encircled by new collaborators, vocalists Luciano George Lorusso and Davide Tolomei, bassist Fabio Fecchio, and drummer Davide Piovesan, Mogicato having touched on to shape with Fields of Asphodel.
Tom Cruise’s Adolf Hitler film pushed back — again
Tom Cruise’s Adolf Hitler film, Valkyrie, has been pushed back yet again — and has this time been postponed until 2009.
The film, which tells the story of the 1944 assassination plot against Hitler, was initially postponed from summer 2008 to this fall; and is now not expected to appear until next year.
“We were originally expecting the film to be released in June,” said a senior executive at one of Britain’s leading cinema chains.
“I know there have been all sorts of problems with this production and we will not be screening it at all this year.”
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Hong Kong director Wong Kar-wai to head Shanghai film festival jury
HONG KONG - Cannes-winning Hong Kong director Wong Kar-wai will head the jury at the Shanghai International Film Festival later this month.
Wong replaces English director Anthony Minghella, who died in London in March of a hemorrhage following surgery.
According to a notice on the Shanghai festival's website Friday, the jury will also include veteran Chinese actress Joan Chen, German producer Ulrich Felsberg, Danish director Bille August, Israeli writer Gila Almagor, Japanese director Kaori Momoi and Chinese director Huo Jianqi.
The jury will award the festival's top Jin Jue Award.
This year's competition lineup includes movies from China, Europe, Japan, Argentina, South Korea, Lithuania, Russia, the Czech Republic and New Zealand.
Known for his moody visuals and melancholy soundtracks, Wong won best director at the Cannes Film Festival in 1997 for the gay romance "Happy Together."
A spokeswoman said earlier that the festival is planning a retrospective of Minghella's work.
The Shanghai festival is scheduled to run from June 14-22.
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On the Net: Shanghai International Film Festival: http://www.siff.com
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